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Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities

Fig 8

Estimated dependence of killing efficacies on pulsed peptide concentrations λ with 95% confidence intervals from bootstrap replicates.

The values for the chronic treatment group (green) are clearly larger than values for the acute (red) and memory (blue) groups. The confidence intervals were calculated by determining the 2.5% and 97.5% percentiles of the distribution of $k(k_{\mathrm{\text{max}}},{\lambda }_{\frac{1}{2}},\lambda )$ values for all bootstrapped parameter pairs $(k_{\mathrm{\text{max}}},{\lambda }_{\frac{1}{2}})$ (where 1000 parameter pairs were evaluated) at each concentration λ.

doi: https://doi.org/10.1371/journal.pcbi.1004178.g008