Emergent Systems Energy Laws for Predicting Myosin Ensemble Processivity
Fig 7
Master curve that predicts processive lifetime of ensembles composed of many different myosin isoforms.
Processive lifetimes for isoforms when adjusted system energy consumption E* varies. Isoforms are identical to Fig 6A, except for additional low (δ+ = 5nm, kon = 1000s−1, and koff = 1500s−1) and high (δ+ = 15nm, kon = 3000s−1, and koff = 3500s−1) isoforms, which demonstrate the master curve holds as multiple myosin parameters are altered. The master curve analytically captures the overall response predicted through the unified expression , with A ≈ 14.5 and B ≈ 4.5(10−4). Here, processive lifetime is predictable regardless of individual myosin configuration and the master curve asymptotes are indicative of energy thresholds for perpetual processivity.