De Novo Design and Experimental Characterization of Ultrashort Self-Associating Peptides
Figure 4
Electron micrographs depicting structures of aromatic tripeptides after dissolving in water.
(A) Ac-MYD; 5 mg/mL, magnification: 20000×, (B) Ac-YLD; 40 mg/mL, magnification: 250×, (C) Ac-YYD (precipitate); 40 mg/mL, magnification: 20000×, (D) Ac-YYD (supernatant); 40 mg/mL, magnification: 10000×. In the hydrogel, Ac-MYD formed densely packed fibers (thickness: ∼150 nm). Ac-YLD readily formed large micrometer-sized crystals. In the two phases of Ac-YYD, fibrillar structures (thickness: ∼50 nm) were present in the gelatinous precipitate whereas only amorphous structures were present in the solution.