Investigation of Inflammation and Tissue Patterning in the Gut Using a Spatially Explicit General-Purpose Model of Enteric Tissue (SEGMEnT)
Figure 1
Modular control structure for SEGMEnT.
A simple representation of SEGMEnT's modular control structure is shown in Panel A: morphogenesis cell signaling determines cell behavior, the aggregate of which defines the tissue morphology. An inflammatory module acts as a controller on the morphogenesis processes. Because of the structure/function relationship in gut epithelial tissue the tissue morphology further modulates the morphogenesis cell signaling. Panel B demonstrates future planned control modules to be added to SEGMEnT in order to expand its functional representation (boxes and connectors with dashed lines).