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The Role of Multiple Marks in Epigenetic Silencing and the Emergence of a Stable Bivalent Chromatin State

Figure 4

The zero velocity line: Section of phase diagram for varying Sir2 deacetylation activity () and Sir recruitment (), and fixed Sas2 activity () and Dot1 activity ().

For limited supply of silencer proteins the system self-adjusts the parameter for changing to settle on the zero velocity line (determined from simulations) drawn in gray.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1003121.g004