Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity
Figure 3
Peroxisome proliferator-activated receptor (PPAR) γ suppresses T helper (Th)17 cell differentiation and upregulates FOXP3 expression in vivo.
(A–D) Computational simulation of the effect of PPARγ deficiency on differentiation from a naïve state into either Th17 or iTreg phenotypes. (E) Th17 cell accumulation in spleens of recipients of wild-type versus PPARγ null CD4+ T cells. (F) Treg cell accumulation in spleen, mesenteric lymph nodes (MLN) and lamina propria (LP) of SCID recipient mice.