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The Role of Exposure History on HIV Acquisition: Insights from Repeated Low-dose Challenge Studies

Figure 7

Power of the experiments to establish susceptibility differences between animals.

A Power estimates are shown as a function of the effect size measured by the variance parameter . The different curves are generated with the same number of animals and maximum challenge repeats as the datasets indicated in the legend. The dashed line shows the level of susceptibility variance (), for which an experiment with the same number of animals and maximum challenge repeats as the one in Hansen et al (2011) has a power larger than 0.95. B Histogram of a susceptibility distribution with . A susceptibility distribution more heterogeneous than the one shown can be ruled out with 95% probability.

doi: https://doi.org/10.1371/journal.pcbi.1002767.g007