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Theory on the Coupled Stochastic Dynamics of Transcription and Splice-Site Recognition

Figure 6

A–B. Genome-wide normalized average level of transcripts with m exons in the kth tissue (hm,k, Eq. 16) in mouse (A) and human (B).

Variation around these average signals is reported in Figure S4. The data for this figure come from exon microarray experiments (Materials and Methods). These plots show a broad maximum approximately centered around m∼32 exons (arrow). The dashed line shows the approximate average exon position in base pairs on the secondary y axis. C–D. Genome-wide normalized average level of transcripts with m exons in the kth tissue (hm,k, Eq. 16) in human (C) and mouse (D). The data for this figure come from RNAseq experiments (Materials and Methods) (cf. data in Figure 6 from microarray data).

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1002747.g006