In silico Experimentation of Glioma Microenvironment Development and Anti-tumor Therapy
Figure 2
(a) Change of concentrations for all 15 cytokines in the microenvironment over a period of one year. (b) Normalized cytokine concentration change over a period of one year. It shows three types of cytokine dynamics based upon the temporal traces. TNF-α peaks at the end of phase I. IL10 and PGE2 show constant increase regardless the growth phases of glioma cells. Other cytokines are apparently correlated to the three-phase growth dynamics.