A Peptide Filtering Relation Quantifies MHC Class I Peptide Optimization
Figure 5
Filtering relation of MHC class I peptide optimization.
(A) Consider a population of MHC complexes containing peptides with off-rate . denotes the expected number of MHC complexes that will egress before the peptide can escape. denotes the expected proportion of egressed MHC complexes that will contain peptides with off-rate . This defines a measure of peptide optimization. We plot and as functions of for three peptides with different off-rates and the same initial populations. Maximal optimization is achieved when , with (dashed lines). (B) Consider a population of tapasin-MHC complexes containing peptides with off-rate . denotes the expected number of MHC complexes that will unbind from tapasin and egress before the peptide can escape, where . is defined as in A. We plot and as functions of with (black line in A). Maximal optimization is achieved when , with .