Causal Modeling Using Network Ensemble Simulations of Genetic and Gene Expression Data Predicts Genes Involved in Rheumatoid Arthritis
Figure 3
10-fold knockdown of IL32 modulates number of swollen joints.
Plots of simulated number of tender joints, swollen joints, pain and C-reactive protein concentrations in response to a 10-fold knockdown in gene expression of cytokine IL32 in A. pretreated subjects and B. TNF-α blocker treated subjects. The effects are only predicted in pre-treated patients, suggesting a dependence on TNF-α signaling. The largest predicted effect is to modulate the number of swollen joints.