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Causal Modeling Using Network Ensemble Simulations of Genetic and Gene Expression Data Predicts Genes Involved in Rheumatoid Arthritis

Figure 3

10-fold knockdown of IL32 modulates number of swollen joints.

Plots of simulated number of tender joints, swollen joints, pain and C-reactive protein concentrations in response to a 10-fold knockdown in gene expression of cytokine IL32 in A. pretreated subjects and B. TNF-α blocker treated subjects. The effects are only predicted in pre-treated patients, suggesting a dependence on TNF-α signaling. The largest predicted effect is to modulate the number of swollen joints.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1001105.g003