Gene Expression Network Reconstruction by Convex Feature Selection when Incorporating Genetic Perturbations

doi:10.1371/journal.pcbi.1001014

Gene Expression Network Reconstruction by Convex Feature Selection when Incorporating Genetic Perturbations

Figure 1

Example of biological relationships that can be reconstructed by the algorithm.

An expression Quantitative Trait Locus (eQTL) directly alters the expression level of Gene A, a relationship that we represent in our network model with the parameter . This gene in turn has an effect on Gene B through an unobserved pathway represented by the ‘Factors’ node. While these factors are unobserved we can still infer that there is a regulatory effect of Gene A on the downstream Gene B, which is represented in our network model by the parameter .

doi: https://doi.org/10.1371/journal.pcbi.1001014.g001