Modelling Vesicular Release at Hippocampal Synapses
Figure 2
(A) The neurotransmitter release profile with no external stimulus illustrating the basal release rate. This steady state release profile is a distinct characteristic of the calcium sensor and is independent of geometry. The transient seen in the data is due to starting the simulation off with the sensor in the completely unbound state. (B) Calcium sensitivity of neurotransmitter release response for a range of distances, lc between the calcium sensor and the VDCCs. The VDCC number is adjusted to give the release probability. A set of non-overlapping curves emerge for various distances. Local peak calcium concentration at the site of the active zone is a measure that is modulated by spatial details.