Modeling and Dynamics of the Inward-Facing State of a Na+/Cl− Dependent Neurotransmitter Transporter Homologue
Figure 1
The crystal structure of LeuT.
Views of the LeuT structure as would be seen along the plane of the lipid bilayer, oriented such that the upper side represents the extracellular half. Left: The pseudosymmetric 5+5 repeat is shown in color (green: first repeat, TM1 to TM5; pink: second repeat, TM6 to TM10) with the two broken helices in the core, TM1 and TM6, shown in ribbon representation. The rest of the protein, including TM11 and TM12 are in gray. Bound ions are in yellow, and the substrate, leucine, is colored by element name (H: white, C: gray, N: blue, O: red). TM10 is transparent for clarity. Center: A 180
-rotated view of the structure is shown. TM5 is transparent for clarity. Right: The outer scaffolding helices, TM4, TM5, TM9, and TM10, are shown separated (above) from TM1, TM2, TM3, TM6, TM7, and TM8 (below) for clarity.