Identifying Tightly Regulated and Variably Expressed Networks by Differential Rank Conservation (DIRAC)
Figure 3
Example of a tightly regulated network in normal prostate.
A simplified diagram of the SET network, comprising 11 signaling proteins involved in granzyme mediated apoptosis, is shown in the center. The NP rank template for the network is highlighted yellow, and each unique ranking observed in NP samples is shown to the right with mismatches highlighted red. The histograms at the bottom demonstrate the increased variation in ranking in PT and MT, indicated by greater number of mismatches from the respective rank templates.