On the Conservation of the Slow Conformational Dynamics within the Amino Acid Kinase Family: NAGK the Paradigm
Figure 8
Conservation of the lowest frequency modes of motion among the AAK family members.
Correlation cosines between the ten slowest modes of EcNAGK and those of three other members of the AAK family. (A) Dimeric PfCK. (B) EcNAGK-like dimer of TmNAGK. (C) Monomer of PfUMPK. Ribbon diagrams represent the structure of the corresponding dimers of the AAK family that are compared with EcNAGK. The C- and N-domains are colored green and yellow. In panel B, the N-terminal helix (red) is a key element for the hexamerization of TmNAGK. In panel C, one of the monomers is shadowed to highlight that it has been considered as the coupling environment of the monomer that is being compared with a monomer of EcNAGK.