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A Hidden Markov Model for Single Particle Tracks Quantifies Dynamic Interactions between LFA-1 and the Actin Cytoskeleton

Figure 7

Schematic diagram of LFA-1 interactions and experimental conditions.

A schematic diagram showing the putative interaction between LFA-1 and a binding partner (e.g. talin) associated with the actin cytoskeleton, and the pharmacological agents used to perturb the system. cyto D: cytochalasin D; lova: lovastatin; cal-I: calpain inhibitor I. Additionally, PMA was used to activate the cells. See reference [22] for details of treatment conditions.

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1000556.g007