Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery
Figure 1
Diagram of the five datasets and splicing signal scores for each dataset.
(A) Diagram depicting the three core datasets and the two control datasets used throughout the study. Each dataset is represented by an illustration of an Alu sequence in the antisense orientation. The right and left arms are indicated, along with the typical poly-T stretch located at the 5′ end of each arm. Boxes in the left and right arms mark the potentially exonizing sequence. Solid box borders mark exon boundaries derived based on EST data, whereas dashed borders mark exon boundaries based on bioinformatic predictions, as indicated by the legend on the upper right. The exons in the exonizing groups and in the corresponding control groups, were visualized in the same colors, to emphasize that the latter serves as a control to the former. (B–E) 3′ss and 5′ss scores in the two arms of the Alu element across the different core datasets, as well as for the relevant control dataset.