Astrocytic Mechanisms Explaining Neural-Activity-Induced Shrinkage of Extraneuronal Space
Figure 5
Predicted dynamics of [TMA+]o and [K+]o in wild type and AQP4 knockout.
Predicted activity-dependent ECS volume dynamics in wild type (blue) and AQP4 knockout (red) obtained by numerical solution of model equations (3) (see Methods) from t = 0 s to t = 100 s with enhanced neural activity for 10 s<t<30 s, using the parameter sets that satisfy all imposed empirical constraints for mc5 without (A) and with (B) active water transport through NKCC1. For figure details, see legend to Figure 4. In both plots, the upper insets show the AQP4-mediated water flux relative to zero, and lower insets display the dynamics of ECS potassium levels.