Deterministic Mechanical Model of T-Killer Cell Polarization Reproduces the Wandering of Aim between Simultaneously Engaged Targets
Figure 6
Dependence of the oscillations within the synaptic area on the pulling force density.
(A–C) The three types of oscillations that are predicted correspondingly with low, intermediate, and high values of the pulling force density. The centrosome trajectory is plotted in the x and z coordinates that are the same as in Figure 4 (x parallel and z perpendicular to the synapse). In (A), the pulling force density f = 100 pN/µm, in (B), f = 143 pN/µm, and in (C), f = 200 pN/µm. Microtubule length, 16 µm; effective cytoplasm viscosity, 2 pN s/µm2. (D) The mean period of oscillations parallel and perpendicular to the synapse, as a function of the pulling force density. The error bars are S.E. (insignificant in size for most data points). Microtubule length, 16 µm; effective cytoplasm viscosity, 2 pN s/µm2. (E) The mean (solid line) and the characteristic minimum and maximum (dashed lines) of the centrosome distance from the synapse, as a function of the pulling force density. The minimum and maximum attained during each period were averaged over many periods to obtain the values of the minimum and maximum that are characteristic of the given force density. The error bars in this plot show the standard error associated with the statistical estimation of the characteristic minimum and maximum values. Microtubule length, 16 µm; effective cytoplasm viscosity, 2 pN s/µm2. (F) The peak deviation of the centrosome from the midpoint (amplitude) in oscillations parallel to the synapse (x) vs. the centrosome distance from the synapse z at the moment when the peak deviation was achieved. The datapoints are plotted for the indicated values of the pulling force density. Microtubule length, 16 µm; effective cytoplasm viscosity, 2 pN s/µm2.