A Dual Receptor Crosstalk Model of G-Protein-Coupled Signal Transduction
Figure 1
The model for crosstalk between the Gαi and Gαq pathways depends on both differential specificity and activity for Gαi, Gαq, and Gβγ interactions with PLCβ3 and PLCβ4 to catalyze PIP2 hydrolysis and calcium-dependent feedback control mediated by GRK and PKC.
Selected model parameters are informed by calcium measurements taken for various ligand doses on wild-type and cell lines with shRNAi knockdowns on the proteins shown in red.