Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress
Figure 6
ARACNE algorithm results showing connections to genes Nqo1 and Nfe212 (Nrf2).
Results of ARACNE runs on microarray data showing extension of the Nfe212 (Nrf2) network from Nqo1, one of its targets. Transcriptional regulatory interactions involving Nrf2 and Nqo1 as determined using the ARACNE algorithm. Across 260 microarrays, profiles of genes categorized by the Gene Ontology as participating in the response to oxidative stress were examined. The DPI tolerance was set at 0.15; p = 1e-7. The nodes represent genes and the lines (edges) between them represent transcription regulation relationships. Interactions involving Nrf2 (Gene Symbol: Nfe2l2) and Nqo1 (one of its regulatory targets) are depicted. Multiple edges between two nodes indicate multiple array probe-sets on the arrays referencing the same gene.