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NCX1 represents an ionic Na⁺ sensing mechanism in macrophages

Fig 10

Graphical summary.

NCX1 is required for Na⁺ entry and Ca²⁺ loss upon exposure of MΦs to HS conditions. In LPS-stimulated MΦs, NCX1 is required for HS-boosted NFAT5 accumulation and NO production. Moreover, NCX1 is required for enhanced autolysosome formation and bacterial removal upon HS exposure. HS, high salt; LPS, lipopolysaccharide; MΦ, monocyte/macrophage-like cell; NCX, Na⁺/Ca²⁺ exchanger; NFAT5, nuclear factor of activated T cells 5; NO, nitric oxide.

doi: https://doi.org/10.1371/journal.pbio.3000722.g010