Early uneven ear input induces long-lasting differences in left–right motor function
Fig 1
Asymmetric motor behavior in mice is associated with inner ear dysfunction.
(A) Thirty-second trace of an Slc12a2K842*/K842* and control mouse. Turns: blue, CC; red, C; green, none. (B) The majority of mutant mice have a bias in the C or CC direction. Slc12a2K842*/K842*, C: n = 22; CC: n = 17; NP: n = 3. Foxg1Cre/+;Slc12a2fx/fx, C: n = 11; CC: n = 10. BAC 316.23, C: n = 3; CC: n = 5; NP: n = 1. Pax2-Cre;Tbx1fx/fx, C: n = 4; mean ± SEM. See also S1 Data. (C) The directional preference is stable over time. Mean percent of clockwise circles: Slc12a2K842*/K842* C turners, day 1 versus 5, p > 0.9999; CC turners, day 1 versus 5, p > 0.9999; Foxg1Cre/+;Slc12a2fx/fx C turners, day 1 versus 31, p > 0.9999; CC turners, day 1 versus 31, p = 0.42. Mean ± SEM, repeated measures ANOVA with Bonferroni multiple comparison test. See also S1 Data. BAC, bacterial artificial chromosome; C, clockwise; CC, counterclockwise; NP, no preference; SEM, standard error of the mean.