Prediction of drug cocktail effects when the number of measurements is limited
Fig 3
To define different models, we scanned the log-linear model family over α while setting β = 1 − (M − 1)α and calculated the R2 values.
The maximal R2 occurs close to α = 1/(M − 1) and β = 0, which is the definition of the pairs model. The left panel is a comparison between the pairs model, the Bliss model, and the model defined by the α with the highest R2. The left panel is the R2 values of α = 0:0.05:1. The rows are for M = 3, 4, and 5, respectively.