Structural Mechanism of ER Retrieval of MHC Class I by Cowpox
Figure 7
CPXV203 co-opts the KDELR to retrieve MHCI from the Golgi.
Comparison of the separate but complementary strategies employed by CPXV012 and CPXV203 to downregulate MHCI. CPXV012 impairs nascent MHCI folding by inhibiting TAP, while CPXV203 selectively binds mature MHCI in the low pH environment found in the ERGIC-Golgi and then uses the KDELR to return to the ER where KDELR/CPXV203/MHCI can rapidly dissociate.