Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent
Figure 6
After disassembly of the vasculature by TBZ, washout of the drug leads to partial recovery of the vascular network.
Two time series are shown in (A) and (B), imaged as in Figure 5. Following washout, cells dissociated by TBZ treatment recommence cell elongation and connection. Individual cells are indicated by arrows/asterisks. Scale bar in (A), 50 µm; in (B), 40 µm.