Desynchronization of Neocortical Networks by Asynchronous Release of GABA at Autaptic and Synaptic Contacts from Fast-Spiking Interneurons
Figure 2
AP frequency and train duration required to induce delayed self-inhibition.
(A and B) Current-clamp recordings from a FS interneuron showing increase of sIPSPs following directly evoked spike trains of various durations at frequencies of 100 (A) and 200 Hz (B). (C) Graph showing the relationship between the duration and frequency of trains and the average increase in delayed sIPSPs (n = 6). For this analysis, we used the SD of the mean membrane potential noise (a measure of asynchronous release) normalized to its pre-train level to quantify the change in spontaneous IPSPs (see Materials and Methods).