Transcription Factors Bind Thousands of Active and Inactive Regions in the Drosophila Blastoderm
Figure 10
New Targets of Maternal and Gap Transcription Factors
ChIP/chip oligonucleotide ratio scores for selected new targets.
(A) Bound regions found near well-characterized A-P target genes hb and h, but which do not overlap known CRMs (shown in grey). For example, the binding 22 kb upstream of h is likely to be a novel h CRM because the other genes in proximity are not transcribed in the early embryo.
(B) Genes transcribed in the early embryo that have no known function but are bound at moderate to high levels by multiple gap factors. In the left panel, CG13333/CG13334 loci, and the right, CG15876/CG13713 loci are shown.
(C) miRNA genes that are actively transcribed in early embryos such as the gene that produces mir3, 4, 5, 6–1, 6–2, 6–3, 286, and 309 (left) and the mir-10 gene (right). See Table S3 for more details on binding to miRNA genes.
(D) Binding in the region of D-V genes rho, twi, zen, and sna.