Structural and Functional Diversity of the Microbial Kinome
Figure 4
Sequence Logos Depicting Conservation of Core Motifs and Neighboring Sequences across Most Kinase Families and Selected CAK Subfamilies
Motifs are GxGxxGxxxx, VAIK, E, LxxLH, xxHxDxxxxNxx, xxDFGxx, and Dxx. The size of the letters corresponds to their information content [54]. Families with less than 100 members (BLRK, GLK) are omitted. The diverse CAK family is represented by four distinct subfamilies: APH contains many aminoglycoside resistance kinases and ChoK includes most ChoKs, while FadE and chloro are less well described. For the HRK family, the first two motif logos omit the viral subfamily that lacks these motifs.