Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers
Figure 1
Density of Predicted ESEs and SNPs along Human Exons
RESCUE-ESE hexamers were searched against a database of 121,000 internal human exons. ESE density (blue curve) was determined as the fraction of hexamers beginning at the given exon position in this dataset that were contained in the RESCUE-ESE set. SNP density (red curve) was determined analogously using SNPs from dbSNP mapped to the exon database. Both curves were smoothed by averaging the densities over a leading (3′ss) or lagging (5′ss) window of ten nucleotides.