Figures
The Spatio-temporal Dynamics of Drosophila Eye Disc Development
A Drosophila epithelium expressing a GFP-tagged form of the morphogen Hedgehog (GFP:Hh, in green). The circles mark a photo-bleached area of the epithelium in a FRAP experiment aimed at determining the Hh effective diffusion coefficient. This coefficient, along with others, was used to parameterize the computational model of the growing eye disc that we developed. The model is based on regulatory interactions that have been experimentally determined and was used to explore how the signaling patterns during development affect the movement of the signaling wave sweeping across the tissue and impact on tissue growth. Fried et al.
Image Credit: Fried et al.
Citation: (2016) PLoS Computational Biology Issue Image | Vol. 12(9) September 2016. PLoS Comput Biol 12(9): ev12.i09. https://doi.org/10.1371/image.pcbi.v12.i09
Published: September 30, 2016
Copyright: © 2016 Fried et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A Drosophila epithelium expressing a GFP-tagged form of the morphogen Hedgehog (GFP:Hh, in green). The circles mark a photo-bleached area of the epithelium in a FRAP experiment aimed at determining the Hh effective diffusion coefficient. This coefficient, along with others, was used to parameterize the computational model of the growing eye disc that we developed. The model is based on regulatory interactions that have been experimentally determined and was used to explore how the signaling patterns during development affect the movement of the signaling wave sweeping across the tissue and impact on tissue growth. Fried et al.
Image Credit: Fried et al.