Influence of low tital volume ventilation on curative effect and prognosis of patients with high risk ALI / ARDSChinese Full Text
WANG Yisheng;LI Hongyun;FENG Yonghai;QIN Chao;LIU Peijie;Department of Respiratory Diseases,the Fifth Affiliated Hospital,Zhengzhou University;
Abstract: Aim: To explore the influence of low tital volume ventilation on curative effect and prognosis of patients with high risk acute lung injury（ ALI） / acute respiratory distress syndrome（ ARDS）. Methods: From August,2012 to May,2013 in the Fifth Affiliated Hospital of Zhengzhou University,according to the inclusion standard,we selected 68 patients with high risk ALI / ARDS in Respiratory Intensive Care Unit（ RICU）. All the patients were allocated into two groups: 36 patients（ low tidal volume group） were given low tidal volume ventilation（ VT 6 8 mL / kg）,while 32 patients（ conventional tidal volume group） were given conventional tidal volume ventilation（ VT 10 12 mL/kg）. The indicators such as blood gas analysis results,the expression levels of inflammatory mediators（ TNF-α,IL-6） in the serum and bronchoalveolar lavage fluid were collected respectively at 0 h,48 h,96 h after mechanical ventilation; the incidence of ALI / ARDS,duration of mechanical ventilation,RICU stay,hospital stay and total mortality in the two groups were compared. Results: Compared with initiation of mechanical ventilation in both groups,the levels of TNF-α and IL-6 in serum decreased gradually,and the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid declined significantly at 96 h after mechanical ventilation; compared with the conventional tidal volume group,the levels of inflammatory mediators in the low tidal volume group declined more significantly（ P ＜ 0. 05）. Compared with the conventional tidal volume group,the incidence of ALI / ARDS,duration of mechanical ventilation,RICU stay,hospital stay and total mortality of the low tidal volume group were all improved（ P ＜ 0. 05）. Conclusion: For the patients with high risk ALI / ARDS,ALI / ARDS may be induced by mechanical ventilation. But for the patients who must be treated by mechanical ventilation,low tidal volume ventilation could bring about better effect and prognosis.
Keywords：
high risk of ALI /ARDS; mechanical ventilation; low tidal volume; inflammatory response; curative effect;
- DOI：
10.13705/j.issn.1671-6825.2014.03.029
- Series：
- Subject：
- Classification Code：
R563.8
- Mobile Reading
Read on your phone instantly
Step 1Scan QR Codes
"Mobile CNKI-CNKI Express" App
Step 2Open“CNKI Express”
and click the scan icon in the upper left corner of the homepage.
Step 3
Scan QR Codes
Read this article on your phone.
- HTML
- CAJ Download
- PDF Download
Download the mobile appuse the app to scan this coderead the article.
Tips: Please download CAJViewer to view CAJ format full text.
Download: 350 Page: 393-397 Pagecount: 5 Size: 343K
Citation Network
Related Literature
- Similar Article
- Reader Recommendation
- Associated Author