Expressions of MMP-1,MMP-8 and MMP-13 in gingival tissue of patients with aggressive periodontitisChinese Full Text
ZHAO Hongyu;ZHANG Miao;YUE Xinxin;XUAN Dongying;LIU Linbo;ZHOU Lei;Department of Plastic Surgery,the First Affiliated Hospital,Zhengzhou University;Department of Periodontology,Panyu Branch,Guangdong Provincial Stomatological Hospital; the Affiliated Stomatological Hospital of Southern Medical University;School of Stomatology,Zhengzhou University;Department of Periodontology,Guangdong Provincial Stomatological Hospital;the Affiliated Stomatological Hospital of Southern Medical University;Implant Center,Guangdong Provincial Stomatological Hospital;the Affiliated Stomatological Hospital of Southern Medical University;
Abstract: Aim: To analyze the roles of three collagenases（ MMP-1,MMP-8 and MMP-13） in the pathogenesis of aggressive periodontitis（ AgP）. Methods: The expressions of MMP-1,MMP-8 and MMP-13 in gingival tissue of 30 patients with AgP and 35 healthy controls were detected by immunohistochemistry method. Results: Low expressions of MMP-1,MMP-8 and MMP-13 were shown in healthy control group. Higher expressions of MMP-1 and MMP-8 were found in the AgP group compared with those of healthy control group（ Z = 3. 980 and 2. 990,P ＜ 0. 05）. Conclusion: MMP-1 and MMP-8may play an important role in the development of AgP.
- DOI：
10.13705/j.issn.1671-6825.2014.02.023
- Series：
- Subject：
- Classification Code：
R781.42
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