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Detection of Exposure to Environmental Pesticides During Pregnancy by the Analysis of Maternal Hair Using GC–MS

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Abstract

Several classes of pesticides were extracted from maternal hair by solid-liquid extraction. Analysis of their selected metabolites involved a methanolic/hydrochloric acid methyl ester derivatization and liquid–liquid extraction. Gas chromatography electron impact mass spectrometry was used to detect and quantify the pesticides and metabolites. Recovery of parent compounds and metabolites from the analysis of spiked hair ranged from 87 to 112% with coefficients of variation less than 11%. Limits of detection ranged from 0.031 to 5.88 μg g−1. Analysis of hair samples from pregnant women in the Philippines showed maternal exposure during pregnancy to bioallethrin, propoxur, chlorpyrifos, pretilachlor and malathion.

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References

  1. Schettler T (2001) Environ Health Perspect 109(6):813–816

    CAS  Google Scholar 

  2. Tan BL, Ali Mohd M (2003) Talanta 61:385–391

    Article  CAS  Google Scholar 

  3. Dorea JG, Cruz-Granja AC, Lacayo-Romero ML, Cuadra-Leal J (2001) Environ Res 86:229–237

    Article  CAS  Google Scholar 

  4. Lackmann GM, Schaller KH, Angerer J (2004) Sci Total Environ 329:289–293

    Article  CAS  Google Scholar 

  5. Eskenazi B, Bradman A, Castorina R (1999) Environ Health Perspect 107(Suppl 3):409–419

    CAS  Google Scholar 

  6. Young J, Eskenazi B, Gladstone E, Bradman A, Pederson L, Johnson C, Barr D, Furlong C, Holland N (2005) Neurotoxicology 26:199–209

    Article  CAS  Google Scholar 

  7. Berkowitz G, Wetmur J, Birman-Deych E, Obel J, Lapinski R, Godbold J, Holzman I, Wolff M (2004) Environ Health Perspect 112(3):388–391

    Article  Google Scholar 

  8. Tsatakis AM, Tutudaki MI, Tzatzarakis MN, Psaroudakis K, Dolapsakis GP, Michalodimitrakis MN (1998) Vet Human Toxicol 40(4):200–203

    Google Scholar 

  9. Tutudaki M, Tsakalof AK, Tsatsakis AM (2003) Hum Exp Toxicol 22(3):159–164

    Article  CAS  Google Scholar 

  10. Altshul L, Covaci A, Hauser R (2004) Environ Health Perspect 112(11):1193–1199

    Article  CAS  Google Scholar 

  11. Shin H, Pyo H, Park S (2004) Bull Korean Chem Soc 25(10):1489–1494

    Article  CAS  Google Scholar 

  12. Tutudaki M, Tsatsakis AM (2005) J Anal Toxicol 29:805–809

    CAS  Google Scholar 

  13. Nakao T, Aozasa O, Ohta S, Miyata H (2002) Chemosphere 48:885–886

    Article  CAS  Google Scholar 

  14. Dauberschmidt C, Wennig R (1998) J Anal Toxicol 22:610–611

    CAS  Google Scholar 

  15. Covaci A, Tutudaki M, Tsatsakis AM, Schepens P (2002) Chemosphere 46(3):413–418

    Article  CAS  Google Scholar 

  16. Neuber K, Merkel G, Randow FE (1999) Toxicol Lett 107:189–192

    Article  CAS  Google Scholar 

  17. Harkins DK, Susten AS (2003) Environ Health Perspect 111(4):576–577

    Article  CAS  Google Scholar 

  18. Bielawski D, Ostrea E Jr, Posecion Jr N, Corrion C, Seagraves J (2005) Chromatographia 62:623–629

    Article  CAS  Google Scholar 

  19. Wennig R (2000) Forensic Sci Int 107:5–12

    Article  CAS  Google Scholar 

  20. Gill U, Covaci A, Ryan J, Emond A (2004) Anal Bioanal Chem 380:924–929

    Article  CAS  Google Scholar 

  21. Epa US (1996) Compilation of EPA’s sampling and analysis methods. CRC Press Inc., Boca Ranton p 630

    Google Scholar 

  22. Kitson F, Larsen B, McEwen C (1996) Gas chromatography and mass spectrometry: a practical guide. Academic, London

    Google Scholar 

  23. Schettgen T, Koch H, Drexler J, Angerer J (2002) J Chromatogr B 778:121–130

    Article  CAS  Google Scholar 

  24. Holger K, Angerer J (2001) J Chromatogr B 759:43–49

    Google Scholar 

  25. Armbruster D, Tillman M, Hubbs L (1994) Clin Chem 40(7):1233–1238

    CAS  Google Scholar 

  26. Corrion ML, Ostrea EM, Bielawski DM, Posecion NC, Seagraves JJ (2005) J Chromatogr B 822:221–229

    Article  CAS  Google Scholar 

  27. Tsatsakis A, Tutudaki M (2004) Forensic Sci Int 145:195–199

    Article  CAS  Google Scholar 

  28. Liu S, Pleil JD (2002) J Chromatogr B 769:155–167

    Article  CAS  Google Scholar 

  29. Ormand R, Mc Nett D, Bartels M (1999) J Anal Toxicol 23:35–40

    CAS  Google Scholar 

  30. Barr D, Needham L (2002) J Chromatogr B 778:5–29

    Article  CAS  Google Scholar 

  31. Fritz P, Balikova M (2006) Clinica Chimica Acta 370:17–49

    Article  CAS  Google Scholar 

  32. Talts U, Fredriksson A, Eriksson P (1998) Neurobiol Aging 19(6):545–552

    Article  CAS  Google Scholar 

  33. Rosenstein L, Chernoff N (1978) Bull Environ Contam Toxicol 20:624–632

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was financially supported by the National Institute of Child Health and Development R01HD039428, the Environmental Protection Agency Science to Achieve Results (STAR) R829395, and by the Center Grant P30ES06639 from the National Institute of Environmental Health Sciences. We would like to thank the following members of the research team in the Philippines for the recruitment of subjects and the collection of specimens: Ma. Esterlita Villanueva-Uy, M.D., Essie Ann M. Ramos, M.D., Abner M. Hornedo, M.D., Patrocinio C. Mateo, M.D., Lilibeth R. Avendano, Rubilyn S. Obando, Maribel V. Santiago, Roberta S. Briones, Rozza D. Villavicencio, and Celia C. Santiago.

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Authors and Affiliations

  1. Department of Pediatrics, Wayne State University School of Medicine, 421 E Canfield Boulevard, Detroit, MI, 48201, USA

    N. Posecion Jr, E. Ostrea Jr, D. Bielawski, M. Corrion, J. Seagraves & Y. Jin

  2. University of the Philippines Institute of Child Health and Human Development, Manila, Philippines

    E. Ostrea Jr

Authors
  1. N. Posecion Jr
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  2. E. Ostrea Jr
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  3. D. Bielawski
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  4. M. Corrion
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  5. J. Seagraves
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  6. Y. Jin
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Corresponding author

Correspondence to N. Posecion Jr.

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Posecion, N., Ostrea, E., Bielawski, D. et al. Detection of Exposure to Environmental Pesticides During Pregnancy by the Analysis of Maternal Hair Using GC–MS. Chroma 64, 681–687 (2006). https://doi.org/10.1365/s10337-006-0092-7

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  • DOI: https://doi.org/10.1365/s10337-006-0092-7

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