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Publicly Available Published by De Gruyter January 1, 2009

Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project

  • Mario C. Foti , Sunil K. Sharma , Gaurav Shakya , Ashok K. Prasad , Giovanni Nicolosi , Paolo Bovicelli , Balaram Ghosh , Hanumantharao G. Raj , Ramesh C. Rastogi and Virinder S. Parmar
From the journal Pure and Applied Chemistry
https://doi.org/10.1351/pac200577010091
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Abstract

A wide variety of polyphenolic compounds (i.e., 4-methylcoumarins, xanthones, pyrazoles, and pyrazolylacrylonitriles) have been examined for their antioxidant effect on NADPH-catalyzed liver-microsomal lipid peroxidation with a view to establishing their structure–activity relationship. Dihydroxy-/diacetoxy-4-methylcoumarin derivatives have been shown to be radical scavengers. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells. 1,4-Dihydroxyxanthone showed enhanced antioxidant activity as well as ICAM-1 inhibitory activity.

Keywords: acrylonitriles; antioxidants; coumarins; ICAM-1; lipid peroxidation; peroxyls; pyrazoles; xanthones

Conference

International Symposium on the Chemistry of Natural Products and the 4th International Congress on Biodiversity, International Conference on Biodiversity, International Symposium on the Chemistry of Natural Products, ICOB, ISCNP, Biodiversity, Natural Products, 24th, Delhi, India, 2004-01-26–2004-01-31

Published Online: 2009-01-01
Published in Print: 2005-01-01

© 2013 Walter de Gruyter GmbH, Berlin/Boston

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From the journal
Pure and Applied Chemistry
Pure and Applied Chemistry
Volume 77 Issue 1
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Journal and Issue

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