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Progress in Modern Biomedicine. 2014, (19)

Research Progress of the Major Adhesin Proteins of Mycoplasma PneumoniaeChinese Full Text

WANG Li-qiong;XUE Guan-hua;LI Shao-li;YAN Chao;SUN Hong-mei;Dept. of Bacteriology,Capital Institute of Pediatrics;Dept. of BBacteriology,Capital Institute of Pediatrics;

Abstract: Mycoplasma pneumoniae（M. pneumoniae） is an important human pathogen that causes primary atypical pneumonia,tracheobronchitis, pharyngitis, asthma and autoimmune diseases. Cytadherence of M. pneumoniae to respiratory epithelium is essential to tissue colonization and subsequent pathogenesis. It is a complex multifactorial process requiring the specialized tip organelle that possesses a group of adhesin proteins such as P1, P30, P116 and HMW1-3, et al. The adhesin proteins deficient mutants show lower gliding velocity, reduced cytadherence, and decreased steady-state levels of tip organelle. The standard methods for the diagnosis of M.pneumoniae are culture, serological tests, and PCR. As a fastidious organism, M. pneumoniae can be difficult to isolate. Considerable cross-reactivity exists between the whole cell antigens used in the commercial serological testing assays. Identification of specific protein antigens is crucial to eliminate the risk of cross-reactions among different related organisms. The adhesin proteins P1 and P30 are also testified to be strongly immunogenic in humans and experimental animals infected with M. pneumoniae. Expression of adhesin proteins in heterologous expression systems provides an opportunity to explore the roles of these proteins in pathogenicity and contributes to develop diagnostic reagents and vaccines. In this review we discuss the applications of various adhesin proteins of M. pneumoniae.
Keywords：

Mycoplasma pneumoniae; Adhesion protein; Serodiagnosis; Vaccine;

  • DOI：

    10.13241/j.cnki.pmb.2014.19.041

  • Series：

  • Subject：

  • Classification Code：

    R375.2

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