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Progress in Modern Biomedicine. 2014, (09)

The Study on the Relationship Between PSD-95 and Cerebral Ischemia and their Regulation MechanismsChinese Full Text

LIU Ying-yi;HU Ling-qin;ZHANG Ying;LI Fang-qin;WANG-Jing;PAN Yu-jun;Department of Neurology, The First Affiliated Hospital of Harbin Medical University;

Abstract: PSD-95（postsynaptic density protein-95） which is abundant in postsynaptic density area has complex domains. It interacts with membrane receptors,ion channels, cell adhesion molecules, as well as with signal molecules, gathering into large molecular complexes and playing an important role in synaptic plasticity, learning and memory, pathophysiological disorders of brain. PSD-95 has closely connection with molecular mechanism of cerebral ischemia neuronal injury and apoptosis. Cerebral ischemia cortical shows PSD-95 positive cell number decrease and cellular morphology damage after cerebral ischemia-reperfusion. Therapeutic strategies to dampen NMDAR activity include disruption of the receptor itself, Ca2+blockers,disruption of the NMDAR/PSD-95 interaction, disruption of the PSD-95/nNOS interface,Pharmacological intervention with nNOS inhibitors. It is studied that to inhibit the interaction with PSD-95 complex can ameliorate cerebral ischemia in the middle cerebral artery occlusion（MCAO） mode of rat. Experimental PSD-95 inhibitors reduce the infarct size which is made by transient and permanent focal ischemia in the rat, then recover the corresponding motion function to treat cerebral ischemia. The article mainly studies the relationship of PSD-95 and cerebral ischemia as well as their regulation mechanisms.
Keywords：

PSD-95; Cerebral ischemia; NMDAR;

  • DOI：

    10.13241/j.cnki.pmb.2014.09.052

  • Series：

  • Subject：

  • Classification Code：

    R743

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