Apoptosis induced by Chrysomyia Megacephala Fab Extracts in Human Promyelocytic Leukemia CellsChinese Full Text
TU Linglan;ZHENG Xiaoliang;YAN Dongmei;MA Zhen;PENG Xiaoying;Institute of Materia Medica,Zhejiang Academy of Medical Sciences;Center for Translational Molecular Medicine,Zhejiang Academy of Medical Sciences;
Abstract: To observe the cell apoptosis induced by Chrysomyia Megacephala Fab extracts LXZ-1A in human promyelocytic leukemia cells.Cell viability of HL-60 cells treated with LXZ-1A was measured by MTT assay.LXZ-1A-induced cell morphological changes were observed with light microscope,fluorescence microscope and transmission electron microscope.Cell apoptosis rate was determined by flow cytometric analysis.The IC50（24 h） of LXZ-1A for inhibition HL-60 cell proliferation was（2.26 ± 0.17） mg /mL.The cell treated with LXZ-1A（0.3 1.0 mg /mL）showed typical morphological changes of apoptosis and the apoptotic rate was 8% to 46% for 24 h.Chrysomyia Megacephala Fab extracts LXZ-1A inhibits human promyelocytic leukemia cells proliferation and induces cell apoptosis.
- DOI：
10.13193/j.issn.1673-7717.2014.09.060
- Series：
- Subject：
- Classification Code：
R285.5
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