Clinical and Experimental Study on Effect of Bushen Huoxue Capsule in Treating Varicocele of Kidney Yang Deficiency and Blood Stasis SyndromeChinese Full Text
GAO Enjiang;YU Zhiyong;DU Jing;DONG Wei;REN Anji;BAI Wenjun;Urology Department,Weifang Hospital of TCM;Pathology Department,Weifang Hospital of TCM;Urology Department,People’s Hospital of Beijing University;
Abstract: Objective: By applicating randomized,double-blind,controlled method,to observe the effect of Bushen Huoxue Capsule in treating kidney Yang deficiency and blood stasis syndrome of varicocele and to explore its mechanism.Methods: In the clinical study,65 patients were divided into two groups on random: the treatment group （33 cases treated with Bushen Huoxue Capsule after surgery） and the control group （32 cases treated with clomiphene citrate after surgery）. Before and after treatment,the clinical symptoms,physical sign,endocrine hormone （T,LH,FSH）,sperm routine parameter,and sperm motility parameter were observed. In the experimental study,30 male SD rats were randomly divided into three groups: the sham-operation group,the model control group and the model treatment group. After surgery,rats in the sham-operation group and the model control group were treated with 0. 9% NaCl. Rats in the model treatment group were treated with Bushen Huoxue Capsule. Testicle organizational structure of rats was observed,and Makler grading was made. Results: In the clinical study,Bushen Huoxue Capsule was effective to rectify endocrine dysfunction and improve sperm routine parameter,and sperm motility parameter. The difference between the treatment group and the control group was significant. In the experimental study,the Makler grading of the model treatment group was significantly higher than that of the model control group,and had no significant difference compared with that of the sham-operation group. Conclusion: Surgery combined Bushen Huoxue Capsule is an effective recipe in treating kidney Yang deficiency and blood stasis syndrome of varicocele. Bushen Huoxue Capsule can restore the damage testicle organizational structure of experimental varicocele rats.
- DOI：
10.13193/j.issn.1673-7717.2014.01.063
- Series：
- Subject：
- Classification Code：
R277.5
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