Effect of Different Decocting Time on Contents of Ester-type Alkaloids in Water Decoction of Aconitum carmichaeli DexbChinese Full Text
KUANG Qingfen;HOU Dabin;SUN Hong;YUE Conghui;College of Life Science and Engineering,Southwest University of Science and Technology;Sichuan Jiangyou Zhongba Aconiti Lateralis Radix Technology Development Company;
Abstract: Objective:To study the effect on total alkaloids and six kinds of ester-type alkaloids in water decoction of Aconitum carmichaeli Dexb.by different decocting time.Methods:The contents of total alkaloids were measured by acid base titration;the six kinds of ester-type alkaloids were tested by HPLC with Agilent ZORBAX Extend-C18.Results:As the extension of decoction time,the change of dissolution rate of total alkaloid in different processed drugs was not obvious.With the different processed drugs,the change law of ester type alkaloid in the process of the decoction was not the same; the content of alkaloid was the lowest; the hydrolysis of alkaloid was most completely.Conclusion:It’s essential to play maximum of pharmacological action and master dose and decoction time appropriately when apply of aconitum carmichaeli in clinic in a high-dose.
- DOI：
10.13192/j.issn.1000-1719.2014.08.064
- Series：
- Subject：
- Classification Code：
R284.1;O657.72
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