Strain identifier

BacDive ID: 14717

Type strain: Yes

Species: Streptococcus anginosus

Strain Designation: Havill III. (R. Lancefield F68A)

Strain history: CIP <- 1987, NCTC, Streptococcus sp. <- 1970 G. Colman <- R. Lancefield <- E.A. Bliss

NCBI tax ID(s): 1328 (species)

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General

@ref: 8913

BacDive-ID: 14717

DSM-Number: 20563

keywords: genome sequence, 16S sequence, Bacteria, microaerophile, mesophilic, human pathogen

description: Streptococcus anginosus subsp. anginosus Havill III. is a microaerophile, mesophilic human pathogen that was isolated from human throat.

NCBI tax id

  • NCBI tax id: 1328
  • Matching level: species

strain history

<- NCTC <- G. Colman <- E.A. Bliss, Havill III. (R. Lancefield F68A)
CCUG 27298 <-- NCFB 2496 <-- NCTC 10713 <-- G. Colman <-- R. C. Lancefield F68A <-- E. A. Bliss strain Havill lll.

doi: 10.13145/bacdive14717.20221219.7.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Lactobacillales
  • family: Streptococcaceae
  • genus: Streptococcus
  • species: Streptococcus anginosus subsp. anginosus
  • full scientific name: Streptococcus anginosus subsp. anginosus (Andrewes and Horder 1906) Jensen et al. 2013

@ref: 8913

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Streptococcaceae

genus: Streptococcus

species: Streptococcus anginosus subsp. anginosus

full scientific name: Streptococcus anginosus subsp. anginosus (Andrewes and Horder 1906) Jensen et al. 2013

strain designation: Havill III. (R. Lancefield F68A)

type strain: yes

Morphology

cell morphology

  • @ref: 69480
  • gram stain: positive
  • confidence: 97.864

colony morphology

  • @ref: 8913
  • type of hemolysis: beta

multimedia

@refmultimedia contentcaptionintellectual property rights
66793EM_DSM_20563_1.jpgelectron microscopic image© HZI/Manfred Rohde
66793EM_DSM_20563_2.jpgelectron microscopic image© HZI/Manfred Rohde
66793EM_DSM_20563_3.jpgelectron microscopic image© HZI/Manfred Rohde
66793EM_DSM_20563_4.jpgelectron microscopic image© HZI/Manfred Rohde
66793EM_DSM_20563_5.jpgelectron microscopic image© HZI/Manfred Rohde

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
8913COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yeshttps://mediadive.dsmz.de/medium/693Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
8913TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)yeshttps://mediadive.dsmz.de/medium/92Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
41326MEDIUM 3 - Columbia agaryesColumbia agar (39.000 g);distilled water (1000.000 ml)

culture temp

@refgrowthtypetemperaturerange
8913positivegrowth37mesophilic
41326positivegrowth37mesophilic
67770positivegrowth37mesophilic

Physiology and metabolism

oxygen tolerance

  • @ref: 8913
  • oxygen tolerance: microaerophile

spore formation

  • @ref: 69480
  • spore formation: no
  • confidence: 98.664

halophily

  • @ref: 69480
  • halophily level: non-halophilic
  • confidence: 94.209

murein

  • @ref: 8913
  • murein short key: A11.05
  • type: A3alpha L-Lys-L-Ala2

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
6838116443D-tagatose-builds acid from
68381320055methyl beta-D-glucopyranoside+builds acid from
683816731melezitose-builds acid from
6838117306maltose+builds acid from
6838127941pullulan+builds acid from
6838128087glycogen-builds acid from
68381606565hippurate-hydrolysis
6838140585alpha-cyclodextrin-builds acid from
6838118333D-arabitol-builds acid from
6838130849L-arabinose-builds acid from
6838117992sucrose+builds acid from
6838116634raffinose+builds acid from
6838127082trehalose+builds acid from
6838130911sorbitol-builds acid from
6838116899D-mannitol-builds acid from
6838116988D-ribose-builds acid from
6838129016arginine+hydrolysis

metabolite production

  • @ref: 68381
  • Chebi-ID: 15688
  • metabolite: acetoin
  • production: yes

metabolite tests

  • @ref: 68381
  • Chebi-ID: 15688
  • metabolite: acetoin
  • voges-proskauer-test: +

enzymes

@refvalueactivityec
8913catalase-1.11.1.6
8913cytochrome-c oxidase-1.9.3.1
68381glycyl tryptophan arylamidase-
68381N-acetyl-beta-glucosaminidase-3.2.1.52
68381pyrrolidonyl arylamidase-3.4.19.3
68381beta-galactosidase-3.2.1.23
68381Alanyl-Phenylalanyl-Proline arylamidase+
68381alkaline phosphatase+3.1.3.1
68381beta-glucuronidase-3.2.1.31
68381beta-glucosidase+3.2.1.21
68381arginine dihydrolase+3.5.3.6

fatty acid profile

  • fatty acids

    @reffatty acidpercentageECL
    48705C14:014.514
    48705C16:023.716
    48705C18:03.218
    48705C16:1 ω5c3.715.908
    48705C16:1 ω7c7.615.819
    48705C16:1 ω9c9.815.774
    48705C18:1 ω7c /12t/9t22.317.824
    48705C18:1 ω9c7.317.769
    48705C18:2 ω6,9c/C18:0 ANTE7.917.724
  • type of FA analysis: whole cell analysis
  • method/protocol: CCUG

API rID32STR

@refADH Argbeta GLUbeta GARbeta GURalpha GALPALRIBMANSORLACTRERAFSACLARADARLCDEXVPAPPAbeta GALPyrAbeta NAGGTAHIPGLYGPULMALMELMLZMbeta DGTAGbeta MANURE
8913++---+---++++---++------++--+-+/--
8913++--+/-+---++++---++------++--+-+/-+
8913++--++---+/-+++---++------++--+-+-
8913++--+/-+----+++---++------+++/--+---

Isolation, sampling and environmental information

isolation

@refsample type
8913human throat
67770Tissue, human (human throat)

isolation source categories

Cat1Cat2Cat3
#Host#Human
#Host Body-Site#Oral cavity and airways#Throat

taxonmaps

  • @ref: 69479
  • File name: preview.99_844.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_4;96_507;97_583;98_670;99_844&stattab=map
  • Last taxonomy: Streptococcus
  • 16S sequence: LC258132
  • Sequence Identity:
  • Total samples: 111895
  • soil counts: 1377
  • aquatic counts: 2504
  • animal counts: 107283
  • plant counts: 731

Safety information

risk assessment

  • @ref: 8913
  • pathogenicity human: yes
  • pathogenicity animal: yes
  • biosafety level: 2
  • biosafety level comment: Risk group (German classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Streptococcus anginosus SK52 = DSM 20563 16S ribosomal RNA gene, partial sequenceJN7871691404ena1000570
20218Streptococcus anginosus ATCC 12395 16S rRNA gene, partial sequenceU02909396ena1000570
8913Streptococcus anginosus strain ATCC33397 16S ribosomal RNA gene, partial sequenceAF1046781573ena1000570
67770Streptococcus anginosus gene for 16S ribosomal RNA, partial sequence, strain: JCM 12993LC2581321449ena1328
67770S.anginosus 16S rRNAX583091334ena1328

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Streptococcus anginosus NCTC10713GCA_900636475completencbi1328
66792Streptococcus anginosus SK52 = DSM 20563 ATCC 33397GCA_002088025contigncbi1000570
66792Streptococcus anginosus SK52 = DSM 20563 DSM 20563GCA_000373605scaffoldncbi1000570
66792Streptococcus anginosus SK52 = DSM 20563 SK52GCA_000474055contigncbi1000570
66792Streptococcus anginosus SK52 = DSM 20563 SK52GCA_000214555contigncbi1000570
66792Streptococcus anginosus SK52 = DSM 20563GCA_019930105contigncbi1328
66792Streptococcus anginosus SK52 = DSM 205631000570.9wgspatric1000570
66792Streptococcus anginosus SK52 = DSM 205631000570.3wgspatric1000570
66792Streptococcus anginosus SK52 = DSM 205631000570.8wgspatric1000570
66792Streptococcus anginosus SK52 = DSM 20563 strain ATCC 333971000570.31wgspatric1000570
66792Streptococcus anginosus strain NCTC107131328.82completepatric1328
66792Streptococcus anginosus strain SK52 = DSM 205631328.317wgspatric1328
66792Streptococcus anginosus DSM 205632515154090draftimg1000570
66792Streptococcus anginosus SK52, DSM 205632602041681draftimg1000570

GC content

@refGC-content
891336.6
6777038-40

External links

@ref: 8913

culture collection no.: DSM 20563, ATCC 12395, ATCC 33397, NCTC 10713, CCUG 27298, LMG 14502, JCM 12993, CCUG 35776, CIP 102921, HAMBI 1525, NCFB 2496

straininfo link

@refpassport
20218http://www.straininfo.net/strains/55063
20218http://www.straininfo.net/strains/55060
20218http://www.straininfo.net/strains/723654

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Pathogenicity1995029Emended descriptions and recognition of Streptococcus constellatus, Streptococcus intermedius, and Streptococcus anginosus as distinct species.Whiley RA, Beighton DInt J Syst Bacteriol10.1099/00207713-41-1-11991Base Composition, DNA, Bacterial/analysis, Humans, Serotyping, Streptococcus/*classification/cytology/genetics/physiologyPhylogeny
Pathogenicity2111871Serogrouping of oral Streptococcus intermedius.Osano E, Tanaka T, Ozeki M, Makita I, Moriyama TMicrobiol Immunol1990Animals, Antigens, Bacterial/*analysis, Bacterial Typing Techniques, Humans, Immunodiffusion, Male, Mouth Diseases/complications/*microbiology, Rabbits, Streptococcal Infections/complications/*immunology, Streptococcus/*classification/immunology/isolation & purificationPhylogeny
Pathogenicity2610299[Taxonomic studies of the Streptococcus intermedius strains isolated from human oral cavities].Fujii YAichi Gakuin Daigaku Shigakkai Shi1989Humans, Mouth/*microbiology, Streptococcus/*classificationPhylogeny
Phylogeny2632666DNA-DNA hybridization studies and phenotypic characteristics of strains within the 'Streptococcus milleri group'.Whiley RA, Hardie JMJ Gen Microbiol10.1099/00221287-135-10-26231989Bacterial Proteins/isolation & purification, DNA, Bacterial/*genetics, Electrophoresis, Polyacrylamide Gel, Nucleic Acid Hybridization, Phenotype, Sequence Homology, Nucleic Acid, Sodium Dodecyl Sulfate, Species Specificity, Streptococcus/analysis/classification/*geneticsEnzymology
Phylogeny8502174Deoxyribonucleic acid relatedness and phenotypic characteristics of oral Streptococcus milleri strains.Taketoshi M, Yakushiji T, Inoue MMicrobios1993DNA Probes, DNA, Bacterial/genetics/*isolation & purification, Humans, Mouth/*microbiology, Phenotype, Sequence Homology, Nucleic Acid, Serotyping, Species Specificity, Streptococcus/classification/*genetics/isolation & purificationEnzymology
Phylogeny8784576Rapid species identification of "Streptococcus milleri" strains by line blot hybridization: identification of a distinct 16S rRNA population closely related to Streptococcus constellatus.Jacobs JA, Schot CS, Bunschoten AE, Schouls LMJ Clin Microbiol10.1128/JCM.34.7.1717-1721.19961996Bacterial Typing Techniques, Base Sequence, DNA Probes/genetics, Genes, Bacterial, Humans, Molecular Sequence Data, Nucleic Acid Hybridization, Phenotype, Polymerase Chain Reaction, RNA, Bacterial/*genetics, RNA, Ribosomal, 16S/*genetics, Species Specificity, Streptococcus/*classification/*genetics/isolation & purificationPathogenicity
Phylogeny10555325A study of small-colony, beta-haemolytic, Lancefield group C streptococci within the anginosus group: description of Streptococcus constellatus subsp. pharyngis subsp. nov., associated with the human throat and pharyngitis.Whiley RA, Hall LM, Hardie JM, Beighton DInt J Syst Bacteriol10.1099/00207713-49-4-14431999Bacterial Typing Techniques, DNA, Bacterial/analysis/genetics, Humans, Nucleic Acid Hybridization, Pharyngitis/*microbiology, Pharynx/*microbiology, Polymerase Chain Reaction, RNA, Ribosomal, 16S/genetics, RNA, Ribosomal, 23S/genetics, Streptococcal Infections/*microbiology, Streptococcus/*classification/genetics/*isolation & purificationPathogenicity
Phylogeny10843047The Streptococcus anginosus species comprises five 16S rRNA ribogroups with different phenotypic characteristics and clinical relevance.Jacobs JA, Schot CS, Schouls LMInt J Syst Evol Microbiol10.1099/00207713-50-3-10732000Adult, Aged, Female, Genes, rRNA, Genetic Variation, Humans, Male, Middle Aged, Molecular Sequence Data, Nucleic Acid Hybridization/methods, Oligonucleotide Probes, Phenotype, RNA, Ribosomal, 16S/*genetics, Sequence Analysis, DNA, Streptococcal Infections/*microbiology/physiopathology, Streptococcus/*classification/genetics/*physiology, Urogenital System/microbiologyPathogenicity
Metabolism11699591Antigenic characterisation of a novel Streptococcus anginosus antigen that induces nitric oxide synthesis by murine peritoneal exudate cells.Sasaki M, Ohara-Nemoto Y, Tajika S, Kobayashi M, Yamaura C, Kimura SJ Med Microbiol10.1099/0022-1317-50-11-9522001Animals, Antigens, Bacterial/*immunology, Cytokines/metabolism, Immunoblotting, Immunodiffusion, Macrophage Activation, Macrophages, Peritoneal/chemistry/*immunology/metabolism, Mice, Mice, Inbred C57BL, Nitric Oxide/*biosynthesis, Nitric Oxide Synthase/metabolism, Nitric Oxide Synthase Type II, Streptococcal Infections/immunology/microbiology, Streptococcus/growth & development/*immunology
Enzymology16055397Dipeptidyl peptidase IV of Streptococcus anginosus: purification and characterization.Fujimura S, Shibata Y, Hirai K, Ueda OEur J Med Res2005Chromatography, Gel, Chromatography, Ion Exchange, Dipeptidyl Peptidase 4/chemistry/*isolation & purification/metabolism, Hydrogen-Ion Concentration, Hydrophobic and Hydrophilic Interactions, Isoelectric Point, Molecular Weight, Sepharose, Streptococcus anginosus/*enzymology, Substrate SpecificityPhylogeny
Pathogenicity16490986The efficacy of povidone-iodine products against periodontopathic bacteria.Nakagawa T, Hosaka Y, Ishihara K, Hiraishi T, Sato S, Ogawa T, Kamoi KDermatology10.1159/0000892082006Aggregatibacter actinomycetemcomitans/drug effects, Anti-Infective Agents, Local/*pharmacology, Fusobacterium nucleatum/drug effects, Gram-Negative Bacteria/*drug effects, Humans, Mouth/*microbiology, Porphyromonas gingivalis/drug effects, Povidone-Iodine/*pharmacology, Prevotella intermedia/drug effects, Streptococcus anginosus/*drug effects
Pathogenicity23594064Identification of beta-haemolysin-encoding genes in Streptococcus anginosus.Asam D, Mauerer S, Walheim E, Spellerberg BMol Oral Microbiol10.1111/omi.120262013Bacterial Proteins/antagonists & inhibitors/*genetics, Escherichia coli/genetics, Genes, Bacterial/*genetics, Genetic Vectors/genetics, Hemolysin Proteins/antagonists & inhibitors/*genetics, Hemolysis/genetics, Humans, Multigene Family/genetics, Mutagenesis/genetics, Mutation/genetics, Open Reading Frames/genetics, Plasmids/genetics, Polyethylene Glycols/pharmacology, Promoter Regions, Genetic/genetics, Protein Processing, Post-Translational/genetics, Sequence Homology, Streptococcus anginosus/*genetics, Streptococcus constellatus/genetics, Streptococcus pyogenes/genetics, Streptolysins/genetics, Virulence Factors/geneticsGenetics
Metabolism29669961Aciduricity and acid tolerance mechanisms of Streptococcus anginosus.Sasaki M, Kodama Y, Shimoyama Y, Ishikawa T, Kimura SJ Gen Appl Microbiol10.2323/jgam.2017.11.0052018Acids/*metabolism/pharmacology, Arginine/metabolism, Culture Media, Dicyclohexylcarbodiimide/pharmacology, Gene Deletion, Hydrogen-Ion Concentration, Hydrolases/genetics/*metabolism, Microbial Viability/drug effects, Proton-Translocating ATPases/antagonists & inhibitors/genetics/*metabolism, Streptococcus anginosus/*drug effects/enzymology/genetics/*physiologyCultivation
Metabolism30192020The fibronectin-binding protein homologue Fbp62 of Streptococcus anginosus is a potent virulence factor.Kodama Y, Ishikawa T, Shimoyama Y, Sasaki D, Kimura S, Sasaki MMicrobiol Immunol10.1111/1348-0421.126462018Adhesins, Bacterial/genetics/*immunology, Animals, Bacterial Adhesion, Bacterial Outer Membrane Proteins/genetics/metabolism, Bacterial Proteins/genetics/immunology/metabolism, Carrier Proteins/metabolism, Cell Line, Disease Models, Animal, Epithelial Cells, Fibronectins/metabolism, Genes, Bacterial, Hep G2 Cells, Humans, Male, Mice, Mice, Inbred BALB C, Recombinant Proteins/immunology, Streptococcus anginosus/genetics/*immunology/*metabolism/*pathogenicity, Streptococcus gordonii/metabolism, Streptococcus mutans/metabolism, Streptococcus pneumoniae/immunology, Streptococcus pyogenes/metabolism, Virulence, Virulence Factors/*immunologyPathogenicity
Phylogeny31053905Streptococcus periodonticum sp. nov., Isolated from Human Subgingival Dental Plaque of Periodontitis Lesion.Lim YK, Park SN, Shin JH, Chang YH, Shin Y, Paek J, Kim H, Kook JKCurr Microbiol10.1007/s00284-019-01695-82019Bacteria, Anaerobic, Bacterial Proteins/genetics, Base Composition, DNA, Bacterial/genetics, DNA-Directed RNA Polymerases/genetics, Dental Plaque/*microbiology, Fatty Acids/analysis, Genome, Bacterial/genetics, Humans, Periodontitis/*microbiology, Phylogeny, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA, Species Specificity, Streptococcus/*classification/genetics/*physiology, Superoxide Dismutase/geneticsGenetics
31105901beta-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune HJ Oral Microbiol10.1080/20002297.2019.16098392019
Phylogeny34417650Streptococcus vaginalis sp. nov., a novel bacterial species isolated from vaginal swabs of a pregnant woman with diabetes.Chao AS, Lin CY, Chao A, Lee YS, Chang YC, Wu HC, Dai YJ, Liao WQ, Kao FC, Chen YSArch Microbiol10.1007/s00203-021-02532-y2021Bacterial Typing Techniques, Base Composition, DNA, Bacterial/genetics, *Diabetes Mellitus, Fatty Acids, Female, Humans, Nucleic Acid Hybridization, Phylogeny, Pregnancy, *Pregnant Women, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA, Streptococcus/geneticsPathogenicity

Reference

@idauthorscataloguedoi/urltitlejournalpubmed
8913Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 20563)https://www.dsmz.de/collection/catalogue/details/culture/DSM-20563
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.10.1099/ijsem.0.004332List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
20218Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.10.1016/j.syapm.2013.11.002StrainInfo introduces electronic passports for microorganisms.Syst Appl Microbiol. 37: 42-50 201424321274
41326Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/14661
48705Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 27298)https://www.ccug.se/strain?id=27298
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
66793Mukherjee et al.10.1038/nbt.3886GEBA: 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life 35: 676-683 201728604660
67770Curators of the JCMhttps://jcm.brc.riken.jp/en/
68381Automatically annotated from API rID32STR
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)