Hemodynamics can be a key factor associated with the onset and progress of aortic aneurysms, which are normally triggered by atherosclerosis. This study is aiming to clarify the aortic aneurysm hemodynamics with consideration of wall deformations and to evaluate the wall shear stresses and energy loss with rigid and deformable vessels by introducing two indices of the pulsatile pressure index (PPI) and the pulsatile energy loss index (PELI). A realistic three-dimensional computational fluid dynamic model of aortic aneurysm is constructed based on medical images and is further connected to a 0-1D model for the whole cardiovascular system, which provides both boundary conditions of pressure and flow-volumetric rate waveforms at inlet and outlet as well as vessel wall deformations. Our result shows that the wall deformation can result in significant differences in a three-dimensional, and hence points to the importance of considering the influence of vessel compliance in evaluation of the pulsatile flow energy loss.