[Background] Food allergies cause damage not only to the intestines of patients but to their livers as well, making it all the more important to discover what drugs are effective in preventing that damage. Accordingly, we studied the effectiveness of Chinese traditional medicine and FOS in helping to prevent damage caused by food allergies.
[Methods] (1) ¹³C-methacetine was used to study the relationship between liver damage and cases of food allergy presentation.(2) Chinese traditional medicine (Hochu-Ekito = TJ-41) was administered orally to mice twice a day for 2 weeks in a drug study of the food allergy model.(3) The effect of FOS on fecal organic acid production was observed in a study of FOS-treated mice.
[Results] (1) As a result of the ¹³CO₂ excretion pattern, the relationship between liver function and food allergies was confirmed.(2) The serum ALT levels decreased in mice treated with TJ-41.(3) Short-chain fatty acids such as butyrate were significantly higher in the FOS-treated group than in the control group.
[Conclusion] Damage not only to the intestines but also the liver of food allergy patients was confirmed. TJ-41 and FOS were found to prevent this allergy-related damage, showing that FOS is very useful for allergic patients.