Thyroid Dysplasia in Wistar Hannover GALAS Rats

Klaus Weber; Rainer Ernst; Heinz Fankhauser; Jerry F. Hardisty; Wolfram Heider; Karla Stevens

doi:10.1293/tox.22.247

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Thyroid Dysplasia in Wistar Hannover GALAS Rats

Klaus Weber, Rainer Ernst, Heinz Fankhauser, Jerry F. Hardisty, Wolfram Heider, Karla Stevens

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Keywords: thyroid gland dysplasia, pituitary dwarfism, GALAS rats

JOURNAL FREE ACCESS

2009 Volume 22 Issue 4 Pages 247-254

DOI https://doi.org/10.1293/tox.22.247

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Abstract

Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid. Heterozygous animals exhibited thyroid dysplasia with normal thyroid hormonal homeostasis and no difference in the incidence of preneoplastic or neoplastic lesions in oncogenicity studies.

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