Transient Increases of Glutamic Acid Decarboxylase 67 Immunoreactivity and Its Protein Levels in the Somatosensory Cortex after Transient Cerebral Ischemia in Gerbils

In Koo HWANG; Ki-Yeon YOO; Hua LI; Ok Kyu PARK; Choong Hyun LEE; Jung Hoon CHOI; Dae Young KWON; Moo-Ho WON

doi:10.1292/jvms.70.1005

Anatomy

Transient Increases of Glutamic Acid Decarboxylase 67 Immunoreactivity and Its Protein Levels in the Somatosensory Cortex after Transient Cerebral Ischemia in Gerbils

In Koo HWANG, Ki-Yeon YOO, Hua LI, Ok Kyu PARK, Choong Hyun LEE, Jung Hoon CHOI, Dae Young KWON, Moo-Ho WON

Author information

In Koo HWANG
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
Ki-Yeon YOO
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
Hua LI
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
Ok Kyu PARK
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
Choong Hyun LEE
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
Jung Hoon CHOI
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
Dae Young KWON
Korea Food Research Institute
Moo-Ho WON
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
Institute of Neurodegeneration and Neuroregeneration, Hallym University

Keywords: GABA, GAD67, gerbil, somatosensory cortex, transient forebrain ischemia

JOURNAL FREE ACCESS

2008 Volume 70 Issue 9 Pages 1005-1010

DOI https://doi.org/10.1292/jvms.70.1005

Details

Abstract

In this study, we investigated changes in glutamic acid decarboxylase 67 (GAD67) immunoreactivity and its protein levels in the gerbil somatosensory cortex after ischemia/reperfusion. GAD67 immunoreactivity was significantly increased in layers III and V of the somatosensory cortex 12 hr after ischemia/reperfusion. Thereafter, GAD67 immunoreactivity was decreased with time after ischemia/reperfusion. GAD67 immunoreactivity in the somatosensory cortex 4 days after ischemia/reperfusion was similar to that in the sham-operated group. In addition, GAD67 protein levels were also significantly increased 12 hr after transient forebrain ischemia. These results suggest that the transient increase of GAD67 immunoreactivity in layers III and V may be associated with responses to transient ischemia-induced neuronal damage.

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