The effect of Korean red ginseng (KRG) on morphologic change and function of the liver was investigated after 70% hepatectomy in rats. The liver weight and hepatocyte proliferation of the KRG treated groups significantly increased compared to those of the control group. KRG inhibited the increase of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, and the number and area of lipid droplets. On the basis of these results, it could be concluded that KRG accelerated the liver regeneration and ameliorated liver injury after hepatectomy in rats.