Presence of surfactant proteins in the uteri and placentae of pregnant mares

Masanari ARAKI; Tadatoshi OHTAKI; Junpei KIMURA; Seiji HOBO; Kazuyoshi TAYA; Nobuo TSUNODA; Hiroyuki TANIYAMA; Shigehisa TSUMAGARI; Yasuo NAMBO

doi:10.1292/jvms.20-0174

Theriogenology

Presence of surfactant proteins in the uteri and placentae of pregnant mares

Masanari ARAKI, Tadatoshi OHTAKI, Junpei KIMURA, Seiji HOBO, Kazuyoshi TAYA, Nobuo TSUNODA, Hiroyuki TANIYAMA, Shigehisa TSUMAGARI, Yasuo NAMBO

Author information

Masanari ARAKI
The Japan Racing Association, Tokyo 320-0856, Japan
Tadatoshi OHTAKI
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan
Junpei KIMURA
College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea
Seiji HOBO
Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Kagoshima 890-0065, Japan
Kazuyoshi TAYA
Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan
Shadai Corporation, 275 Hayakitagenbu, Abira-cho, Yufutsu-gun, Hokkaido 059-1432, Japan
Nobuo TSUNODA
Shadai Corporation, 275 Hayakitagenbu, Abira-cho, Yufutsu-gun, Hokkaido 059-1432, Japan
Hiroyuki TANIYAMA
Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan
Shigehisa TSUMAGARI
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan
Yasuo NAMBO
Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

Keywords: mare, placentae, surfactant protein, uteri

JOURNAL OPEN ACCESS

2021 Volume 83 Issue 7 Pages 1167-1172

DOI https://doi.org/10.1292/jvms.20-0174

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Abstract

Immunohistochemical investigations of the expression of surfactant protein A (SP-A) and surfactant protein D (SP-D) in the uterine and placental tissues of 13 pregnant mares were performed using anti-horse monoclonal primary antibodies. Strong positive reactions for both SP-A and SP-D were observed in the trophoblasts in the microcotyledons of the placentae at 182 to 314 days of gestation; in uterine glandular epithelial cells, faint-to-weak reactions were observed during gestation. This study describes, for the first time, the changes in the SP-A and SP-D expression levels in the endometrium of mares during gestation; the SP-A and SP-D expression levels increased after the second trimester of gestation.

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