Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Tissue Distribution of the Enzymes Concerned with the Biosynthesis of NAD in Rats
Katsumi SHIBATATakashi HAYAKAWAKazuo IWAI
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1986 Volume 50 Issue 12 Pages 3037-3041

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Abstract

There are three NAD biosynthetic pathways: the nicotinic acid-NAD, nicotinamide-NAD, and quinolinic acid (derived from tryptophan)-NAD pathways. To discover the main pathways of NAD biosyntheses in various tissues of the rat, the tissue distribution of nicotinamidase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase, nicotinamide phosphoribosyltransferase, nicotinamide mononucleotide adenylyltransferase, and NAD+ synthetase were investigated. All of the tissues could synthesize NAD from nicotinamide, judging from that the activities of nicotinamide phosphoribosyltransferase and NMN adenylyltransferase detected in all of the tissues. From nicotinic acid, only liver, kidneys, and heart could. Liver and kidney can also synthesize NAD de novo from quinolinic acid.

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© Japan Society for Bioscience, Biotechnology, and Agrochemistry
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