25 April 2024 : Clinical Research
[In Press] Machine Learning-Based Prediction of Helicobacter pylori Infection Study in Adults
Min Liu1ACE, Shiyu Liu2ABDG, Zhaolin Lu3DEF, Hu Chen4CD, Yuling Xu1BF, Xue Gong1CF, Guangxia Chen2AEGDOI: 10.12659/MSM.943666
Med Sci Monit In Press; DOI: 10.12659/MSM.943666
Available online: 2024-04-25, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Helicobacter pylori has a high infection rate worldwide, and epidemiological study of H. pylori is important. Artificial intelligence has been widely used in the field of medical research and has become a hotspot in recent years. This paper proposed a prediction model for H. pylori infection based on machine learning in adults.
MATERIAL AND METHODS
Adult patients were selected as research participants, and information on 30 factors was collected. The chi-square test, mutual information, ReliefF, and information gain were used to screen the feature factors and establish 2 subsets. We constructed an H. pylori infection prediction model based on XGBoost and optimized the model using a grid search by analyzing the correlation between features. The performance of the model was assessed by comparing its accuracy, recall, precision, F1 score, and AUC with those of 4 other classical machine learning methods.
RESULTS
The model performed better on the part B subset than on the part A subset. Compared with the other 4 machine learning methods, the model had the highest accuracy, recall, F1 score, and AUC. SHAP was used to evaluate the importance of features in the model. It was found that H. pylori infection of family members, living in rural areas, poor washing hands before meals and after using the toilet were risk factors for H. pylori infection.
CONCLUSIONS
The model proposed in this paper is superior to other models in predicting H. pylori infection and can provide a scientific basis for identifying the population susceptible to H. pylori and preventing H. pylori infection.
Keywords: Machine Learning; Helicobacter pylori; Clinical Decision Rules
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